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How air pollutants stifle the brain
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How air pollutants stifle the brain

Exposure to fine particulate matter and nitrogen dioxide changes the brain's structure, affecting cognition, memory and body movement. Long-term exposure to air pollutants is linked to an increased risk of neurodegenerative diseases like Alzheimer's and Parkinson's

A 2022 study published in Environmental Pollution showed that exposure to air pollutants affects the brain development of babies in the womb and preadults (9 to 12 years).

The study shows that increased exposure to particulate matter 2.5(small dust particles of 2.5 microns size, PM 2.5) in the first two years of growth of children leads to enlarged putamen. The putamen is a vital brain region that maintains brain-body communication.

The Barcelona Institute for Global Health (ISGlobal) research team found that air pollutants like PM 2.5 and nitrogen dioxide (NO2) alter the structure of white matter in the cerebral cortex. “Similar [structural]changes are seen in psychiatric conditions like mood disorders and autism spectrum disorders,” says Dr Anne-Claire Binter, first author of the study. Also, conditions like schizophrenia, autism spectrum disorders, and obsessive-compulsive spectrum disorders are linked to larger putamen, she adds.

Another 2022 study indicates that the exposure to nitrogen dioxide and PM2.5 are associated with higher levels of beta-amyloid protein deposition in the brain, a hallmark of Alzheimer’s.

How air pollutants stifle the brain1. Exposure to air pollutants during pregnancy can slow down the development process of the brain and muscles of the foetus 2. Air pollution reduces the size of the corpus callosum, located in the centre of the brain and above hypothalamus, which is associated with neurodevelopmental disorders such as ADHD and autism 3. Long-term exposure to pollution increases the incidence and severity of strokes, headaches, dementia risk, Parkinson's disease, and worsening of multiple sclerosis symptoms 4. According to a 2019 study, exposure to traffic pollutants delays cognitive development in students 5. Pollutants can disrupt the immune system, trigger inflammation, and cause oxidative stress. Chronic inflammation in the brain leads to neurodegeneration
How air pollutants stifle the brain | Illustration by Seetha Lakshmi Venu

Editor’s note: This article is the first in a two-part series for the World Environment Day (5 June 2023)

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