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Substantia nigra: its role in Parkinson’s disease
  • 1 min read |
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Substantia nigra: its role in Parkinson’s disease

Parkinson's disease develops when the nerve cells that produce dopamine in the substantia nigra region of the brain begin to die. Decreased dopamine levels cause tremors and rigidity in movement - characteristic symptoms of the disease
  • Written by Varsha Vivek
red tulips on the left top corner and right bottom corner- flowers representing Parkinson's. The top right corner has an image of a person with parkinson's and a doctor. Substantia Nigra- its role in Parkinson's disease Image of a side-view of the brain with an animation of dopamine chemical structure radiating from the midbrain , specifically from right above the basal ganglia, which is right above the amygdala. Substantia nigra is a brain region that sits right in the centre of the brain. Neurons here produce dopamine In Parkinson's these dopaminergic neurons start dying. Two images of the brain from a bottom view where a shrunken substantia nigra can be seen in the case of parkinson's. Dopamine is a neurotransmitter that relays messages for body movement Lack of dopamine causes: Rigidity Tremors Slowness Speech issues Freezing of gait with an image on the right of the text that shows the illustration of the symptoms
The substantia nigra produces dopamine and plays a central role in Parkinson’s disease | Infographic by Varsha Vivek
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